The COVID-19 pandemic related isolation measures have caused rapid changes in academic instructional delivery and social interactions. Similar changes and measures are known to have a long-lasting impact on the general population, with autistic individuals sometimes experiencing even greater difficulties than their nonautistic peers. Autistic individuals are now facing an unprecedented change in their daily routines. Given a growing enrollment of autistic students in universities worldwide, there is a need to develop an understanding of the effects of the COVID-19 related a) rapid changes in the mode of academic instruction delivery and b) unexpected isolation measures on this student population. By drawing on interviews with and a survey of autistic university students in Canada, this study has direct implications for the mitigation of academic and social challenges the autistic student population experiences, and, ultimately, for the retention of autistic students under rapidly changing conditions.